7CDC

Crystal structure of LSD1-CoREST in complex with PRSFLVRRP peptide

7CDC の概要

• エントリーDOI: 10.2210/pdb7cdc/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, PRO-ARG-SER-PHE-LEU-VAL-ARG-ARG-PRO, ... (6 entities in total)
• 機能のキーワード: demethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription-inhibitor complex, oxidoreductase, oxidoreductase-transcription complex, oxidoreductase/transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 92284.07

構造登録者

Kikuchi, M.,Kitagawa, H.,Sato, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (登録日: 2020-06-19, 公開日: 2021-06-23, 最終更新日: 2023-11-29)

• 主引用文献: Kitagawa, H.,Kikuchi, M.,Sato, S.,Watanabe, H.,Umezawa, N.,Kato, M.,Hisamatsu, Y.,Umehara, T.,Higuchi, T.; Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity.; J.Med.Chem., 64:3707-3719, 2021; PubMed: 33754721; DOI: 10.1021/acs.jmedchem.0c01371

実験手法

X-RAY DIFFRACTION (2.64 Å)