7CCB

Crystal structure of the SPRY domain-containing protein 7 (SPRY7)

7CCB の概要

• エントリーDOI: 10.2210/pdb7ccb/pdb
• 分子名称: SPRY domain-containing protein 7 (2 entities in total)
• 機能のキーワード: spry7, spryd7, ccld6, c13orf1, spry domain, unknown function
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40892.41

構造登録者

Yang, J.,Kuang, Z. (登録日: 2020-06-16, 公開日: 2020-10-14, 最終更新日: 2023-11-29)

主引用文献

Yang, J.,Guan, X.,Zhang, D.,Zhao, P.,Guo, S.,Kuang, Z.
Crystal structure of the SPRY domain-containing protein 7 reveals unique structural features.
Biochem.Biophys.Res.Commun., 531:350-356, 2020

PubMed Abstract: The SPRY/B30.2 domain is one of the most abundant protein domains found in eukaryotes. Vast majority of the SPRY domain-containing proteins are multi-domain proteins. The SPRY domain-containing protein 7 (SPRY7, also named C13orf1, and named chronic lymphocytic leukemia deletion region gene 6 protein, CCLD6, encoded by the spryd7 gene) is the smallest SPRY domain protein in human that does not contain other accessory domains. Here we have determined the crystal structure of human SPRY7 at a resolution of 1.62 Å and found that SPRY7 has some unique structural features that are not present in other previously reported SRPY domain structures. Overall, SPRY7 may represent an evolutionary early version of the SPRY domain, and subsequent loop insertions and expansions, residue substitutions, as well as domain combinations have rendered the SPRY domain versatile binding specificities and broad biological functions. These results serve as a useful basis for a profound characterization of the molecular interactions of SPRY7.

PubMed: 32800543
DOI: 10.1016/j.bbrc.2020.07.076

実験手法

X-RAY DIFFRACTION (1.62 Å)