7CA0

Crystal structure of dihydroorotase in complex with 5-fluoroorotic acid from Saccharomyces cerevisiae

Summary for 7CA0

• Entry DOI: 10.2210/pdb7ca0/pdb
• Related: 6L0A 6L0B
• Descriptor: Dihydroorotase, ZINC ION, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (4 entities in total)
• Functional Keywords: dihydropyrimidinase dihydroorotase metalloenzyme, hydrolase
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Total number of polymer chains: 4
• Total formula weight: 167133.04

Authors

Guan, H.H.,Huang, Y.H.,Huang, C.Y.,Chen, C.J. (deposition date: 2020-06-08, release date: 2021-06-09, Last modification date: 2023-11-29)

• Primary citation: Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y.; Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode.; Bioinorg Chem Appl, 2021:2572844-2572844, 2021; PubMed: 34630544; DOI: 10.1155/2021/2572844

Experimental method

X-RAY DIFFRACTION (2.5 Å)