7CA0
Crystal structure of dihydroorotase in complex with 5-fluoroorotic acid from Saccharomyces cerevisiae
Summary for 7CA0
Entry DOI | 10.2210/pdb7ca0/pdb |
Related | 6L0A 6L0B |
Descriptor | Dihydroorotase, ZINC ION, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | dihydropyrimidinase dihydroorotase metalloenzyme, hydrolase |
Biological source | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Total number of polymer chains | 4 |
Total formula weight | 167133.04 |
Authors | Guan, H.H.,Huang, Y.H.,Huang, C.Y.,Chen, C.J. (deposition date: 2020-06-08, release date: 2021-06-09, Last modification date: 2023-11-29) |
Primary citation | Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y. Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode. Bioinorg Chem Appl, 2021:2572844-2572844, 2021 Cited by PubMed: 34630544DOI: 10.1155/2021/2572844 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report