7C9N
Crystal structure of SETDB1 tudor domain in complexed with Compound 1.
Summary for 7C9N
Entry DOI | 10.2210/pdb7c9n/pdb |
Descriptor | Histone-lysine N-methyltransferase SETDB1, 3,5-dimethyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]pyrrolo[3,2-d]pyrimidin-4-one (3 entities in total) |
Functional Keywords | gene regulation-inhibitor complex, gene regulation/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 55929.99 |
Authors | |
Primary citation | Guo, Y.,Mao, X.,Xiong, L.,Xia, A.,You, J.,Lin, G.,Wu, C.,Huang, L.,Wang, Y.,Yang, S. Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60:8760-8765, 2021 Cited by PubMed: 33511756DOI: 10.1002/anie.202017200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.472 Å) |
Structure validation
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