7C8W

Structure of sybody MR17 in complex with the SARS-CoV-2 S receptor-binding domain (RBD)

7C8W の概要

• エントリーDOI: 10.2210/pdb7c8w/pdb
• 分子名称: Synthetic nanobody MR17, Spike protein S1, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: coronavirus, covid-19, nanobody, neutralizing antibody, receptor binding protein, sars-cov-2, s protein, synthetic antibody, vhh., protein binding
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37990.26

構造登録者

Li, T.,Cai, H.,Yao, H.,Qin, W.,Li, D. (登録日: 2020-06-03, 公開日: 2020-06-24, 最終更新日: 2023-11-29)

• 主引用文献: Li, T.,Cai, H.,Yao, H.,Zhou, B.,Zhang, N.,van Vlissingen, M.F.,Kuiken, T.,Han, W.,GeurtsvanKessel, C.H.,Gong, Y.,Zhao, Y.,Shen, Q.,Qin, W.,Tian, X.X.,Peng, C.,Lai, Y.,Wang, Y.,Hutter, C.A.J.,Kuo, S.M.,Bao, J.,Liu, C.,Wang, Y.,Richard, A.S.,Raoul, H.,Lan, J.,Seeger, M.A.,Cong, Y.,Rockx, B.,Wong, G.,Bi, Y.,Lavillette, D.,Li, D.; A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.; Nat Commun, 12:4635-4635, 2021; PubMed: 34330908; DOI: 10.1038/s41467-021-24905-z

実験手法

X-RAY DIFFRACTION (2.77 Å)