7C83

Crystal structure of an integral membrane steroid 5-alpha-reductase PbSRD5A

Summary for 7C83

Entry DOI	10.2210/pdb7c83/pdb
Descriptor	3-oxo-5-alpha-steroid 4-dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywords	steroid reductase, nadph, steroid 3-oxo-delta(4) reduction, oxidoreductase
Biological source	Proteobacteria bacterium
Total number of polymer chains	1
Total formula weight	32656.51
Authors	Ren, R.B.,Han, Y.F.,Xiao, Q.J.,Deng, D. (deposition date: 2020-05-28, release date: 2021-01-27, Last modification date: 2024-04-03)
Primary citation	Han, Y.,Zhuang, Q.,Sun, B.,Lv, W.,Wang, S.,Xiao, Q.,Pang, B.,Zhou, Y.,Wang, F.,Chi, P.,Wang, Q.,Li, Z.,Zhu, L.,Li, F.,Deng, D.,Chiang, Y.C.,Li, Z.,Ren, R. Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism. Nat Commun, 12:449-449, 2021 Cited by PubMed: 33469028 DOI: 10.1038/s41467-020-20675-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation