7C7J

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)

Summary for 7C7J

• Entry DOI: 10.2210/pdb7c7j/pdb
• Descriptor: Ras-related protein Rap-1b, SH3 and multiple ankyrin repeat domains protein 3, GUANOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: shank3, rap1b, spn, ras, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 61649.91

Authors

Xiao, L.X.,Pan, L.F. (deposition date: 2020-05-25, release date: 2021-05-05, Last modification date: 2023-11-29)

• Primary citation: Xu, X.L.,Liu, J.P.,Wang, Y.L.,Wang, Y.,Gong, X.,Pan, L.F.; Mechanistic Insights into the Interactions of Ras Subfamily GTPases with the SPN Domain of Autism-associated SHANK3.; Chin.J.Chem., 38:1635-1641, 2020; DOI: 10.1002/cjoc.202000278

Experimental method

X-RAY DIFFRACTION (2.39 Å)