7C7B

Crystal structure of human TRAP1 with SJT009

7C7B の概要

• エントリーDOI: 10.2210/pdb7c7b/pdb
• 分子名称: Heat shock protein 75 kDa, mitochondrial, 2-azanyl-9-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-6-chloranyl-purin-8-ol (3 entities in total)
• 機能のキーワード: trap1, selectivity, mitochondria, hsp90, anticancer, drug, chaperone
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26178.46

構造登録者

Kim, D.,Yang, S.,Yoon, N.G.,Park, E.,Kim, S.Y.,Kang, B.H.,Lee, C.,Kang, S. (登録日: 2020-05-24, 公開日: 2021-05-26, 最終更新日: 2023-11-29)

• 主引用文献: Yang, S.,Yoon, N.G.,Kim, D.,Park, E.,Kim, S.Y.,Lee, J.H.,Lee, C.,Kang, B.H.,Kang, S.; Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.; Acs Med.Chem.Lett., 12:1173-1180, 2021; PubMed: 34267888; DOI: 10.1021/acsmedchemlett.1c00213

実験手法

X-RAY DIFFRACTION (1.5 Å)