7C6U

Crystal structure of SARS-CoV-2 complexed with GC376

Summary for 7C6U

• Entry DOI: 10.2210/pdb7c6u/pdb
• Descriptor: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
• Functional Keywords: sars-cov-2, main protease, inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 1
• Total formula weight: 34311.10

Authors

Fu, L.,Feng, Y.,Qi, J.,Gao, F.G. (deposition date: 2020-05-22, release date: 2020-09-02, Last modification date: 2023-11-29)

• Primary citation: Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F.; Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.; Nat Commun, 11:4417-4417, 2020; PubMed: 32887884; DOI: 10.1038/s41467-020-18233-x

Experimental method

X-RAY DIFFRACTION (2 Å)