7C6U

Crystal structure of SARS-CoV-2 complexed with GC376

7C6U の概要

• エントリーDOI: 10.2210/pdb7c6u/pdb
• 分子名称: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
• 機能のキーワード: sars-cov-2, main protease, inhibitor, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34311.10

構造登録者

Fu, L.,Feng, Y.,Qi, J.,Gao, F.G. (登録日: 2020-05-22, 公開日: 2020-09-02, 最終更新日: 2023-11-29)

• 主引用文献: Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F.; Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.; Nat Commun, 11:4417-4417, 2020; PubMed: 32887884; DOI: 10.1038/s41467-020-18233-x

実験手法

X-RAY DIFFRACTION (2 Å)