7C6P

Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid

7C6P の概要

• エントリーDOI: 10.2210/pdb7c6p/pdb
• 分子名称: Bromodomain-containing protein 4, 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one (3 entities in total)
• 機能のキーワード: brd4, bd2, 3', 4', 7, 8- tetrahydroxyflavonoid, acute myeloid leukemia, c-myc, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13093.17

構造登録者

Li, J.,Yu, K.,Luo, Y.,Zheng, W.,Liang, W.,Zhu, J. (登録日: 2020-05-22, 公開日: 2021-05-12, 最終更新日: 2023-11-29)

• 主引用文献: Li, J.,Zou, W.,Yu, K.,Liu, B.,Liang, W.,Wang, L.,Lu, Y.,Jiang, Z.,Wang, A.,Zhu, J.; Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.; J Enzyme Inhib Med Chem, 36:903-913, 2021; PubMed: 33820450; DOI: 10.1080/14756366.2021.1906663

実験手法

X-RAY DIFFRACTION (1.73 Å)