7C2V
Crystal Structure of IRAK4 kinase in complex with the inhibitor CA-4948
7C2V の概要
エントリーDOI | 10.2210/pdb7c2v/pdb |
分子名称 | Interleukin-1 receptor-associated kinase 4, 2-(2-methylpyridin-4-yl)-N-[2-morpholin-4-yl-5-[(3R)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide (3 entities in total) |
機能のキーワード | irak4, inhibitor, ca-4948, kinase, cell cycle, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 137394.26 |
構造登録者 | |
主引用文献 | Gummadi, V.R.,Boruah, A.,Ainan, B.R.,Vare, B.R.,Manda, S.,Gondle, H.P.,Kumar, S.N.,Mukherjee, S.,Gore, S.T.,Krishnamurthy, N.R.,Marappan, S.,Nayak, S.S.,Nellore, K.,Balasubramanian, W.R.,Bhumireddy, A.,Giri, S.,Gopinath, S.,Samiulla, D.S.,Daginakatte, G.,Basavaraju, A.,Chelur, S.,Eswarappa, R.,Belliappa, C.,Subramanya, H.S.,Booher, R.N.,Ramachandra, M.,Samajdar, S. Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies. Acs Med.Chem.Lett., 11:2374-2381, 2020 Cited by PubMed: 33335659DOI: 10.1021/acsmedchemlett.0c00255 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.44 Å) |
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