7BUS

Chalcone synthase from Glycine max (L.) Merr (soybean)

7BUS の概要

• エントリーDOI: 10.2210/pdb7bus/pdb
• 分子名称: Chalcone synthase (2 entities in total)
• 機能のキーワード: isoflavonoid, flavonoid, soybean, plant protein, transferase
• 由来する生物種: Glycine max (Soybean)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89296.95

構造登録者

Imaizumi, R.,Mameda, R.,Takeshita, K.,Waki, T.,Kubo, H.,Sakai, N.,Nakata, S.,Takahashi, S.,Kataoka, K.,Yamamoto, M.,Yamashita, S.,Nakayama, T. (登録日: 2020-04-08, 公開日: 2020-08-19, 最終更新日: 2023-11-29)

主引用文献

Imaizumi, R.,Mameda, R.,Takeshita, K.,Kubo, H.,Sakai, N.,Nakata, S.,Takahashi, S.,Kataoka, K.,Yamamoto, M.,Nakayama, T.,Yamashita, S.,Waki, T.
Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean.
Proteins, 2020

PubMed Abstract: Isoflavonoid is one of the groups of flavonoids that play pivotal roles in the survival of land plants. Chalcone synthase (CHS), the first enzyme of the isoflavonoid biosynthetic pathway, catalyzes the formation of a common isoflavonoid precursor. We have previously reported that an isozyme of soybean CHS (termed GmCHS1) is a key component of the isoflavonoid metabolon, a protein complex to enhance efficiency of isoflavonoid production. Here, we determined the crystal structure of GmCHS1 as a first step of understanding the metabolon structure, as well as to better understand the catalytic mechanism of GmCHS1.

PubMed: 32725893
DOI: 10.1002/prot.25988

実験手法

X-RAY DIFFRACTION (2.52 Å)