7BRP
Crystal structure of the 2019-nCoV main protease complexed with Boceprevir
Summary for 7BRP
Entry DOI | 10.2210/pdb7brp/pdb |
Related PRD ID | PRD_002382 |
Descriptor | 3C-like proteinase, boceprevir (bound form) (3 entities in total) |
Functional Keywords | the main protease of 2019-ncov complexed with boceprevir, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 2 |
Total formula weight | 68808.58 |
Authors | Fu, L.F. (deposition date: 2020-03-29, release date: 2020-05-13, Last modification date: 2023-11-29) |
Primary citation | Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F. Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11:4417-4417, 2020 Cited by PubMed: 32887884DOI: 10.1038/s41467-020-18233-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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