7BQI

Crystal structure of FYCO1 RUN domain

7BQI の概要

• エントリーDOI: 10.2210/pdb7bqi/pdb
• 分子名称: FYVE and coiled-coil domain-containing protein 1 (2 entities in total)
• 機能のキーワード: autophagy, cytosolic protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20871.55

構造登録者

Sakurai, S.,Shimizu, T.,Ohto, U. (登録日: 2020-03-24, 公開日: 2020-08-05, 最終更新日: 2024-04-03)

主引用文献

Sakurai, S.,Shimizu, T.,Ohto, U.
Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.
Acta Crystallogr.,Sect.F, 76:326-333, 2020

PubMed Abstract: FYCO1 is a multidomain adaptor protein that plays an important role in autophagy by mediating the kinesin-dependent microtubule plus-end-directed transport of autophagosomes. FYCO1 contains a RUN domain, which is hypothesized to function as a specific effector for members of the Ras superfamily of small GTPases, but its role has not been well characterized and its interaction partner(s) have not been identified. Here, the crystal structure of the FYCO1 RUN domain was determined at 1.3 Å resolution. The overall structure of the FYCO1 RUN domain was similar to those of previously reported RUN domains. Detailed structural comparisons with other RUN domains and docking studies suggested a possible interaction interface of the FYCO1 RUN domain with small GTPases of the Ras superfamily.

PubMed: 32744243
DOI: 10.1107/S2053230X20009012

実験手法

X-RAY DIFFRACTION (1.3 Å)