7BPS

Crystal structure of mouse TEX101

7BPS の概要

• エントリーDOI: 10.2210/pdb7bps/pdb
• 分子名称: Testis-expressed protein 101, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: fertility, spermatogenesis, protein binding
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47732.41

構造登録者

Masutani, M.,Sakurai, S.,Shimizu, T.,Ohto, U. (登録日: 2020-03-23, 公開日: 2020-07-15, 最終更新日: 2024-10-23)

主引用文献

Masutani, M.,Sakurai, S.,Shimizu, T.,Ohto, U.
Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains.
Febs Lett., 594:3020-3031, 2020

PubMed Abstract: Testis-expressed gene 101 (TEX101) is a glycosyl-phosphatidylinositol-anchored glycoprotein essential for sperm fertility and spermatogenesis. TEX101 interacts with lymphocyte antigen 6 complex, locus K (Ly6k) as well as a disintegrin and metallopeptidase domain 3 (ADAM3). Although these proteins are considered essential for fertility, the associated mechanisms remain uncharacterized. Herein, we determined the crystal structure of human and mouse TEX101, revealing that TEX101 contains two tandem Ly6/uPAR (LU) domains. Detailed structural analyses revealed characteristic surfaces of TEX101 that may be involved in the interactions with other proteins or membranes. These results provide the structural basis for the role of TEX101 in fertilization and could contribute to developing diagnostic methods and treatments for infertility or developing male contraceptives.

PubMed: 32608065
DOI: 10.1002/1873-3468.13875

実験手法

X-RAY DIFFRACTION (2.35 Å)