7BOS
Human SIRT2 in complex with myristoyl thiourea inhibitor, No.13
Summary for 7BOS
Entry DOI | 10.2210/pdb7bos/pdb |
Related PRD ID | PRD_002361 |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, Myristoyl thiourea inhibitor, No.13, ZINC ION, ... (5 entities in total) |
Functional Keywords | nad-dependent deacetylase, deacylase, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34089.78 |
Authors | Kudo, N.,Olsen, C.A.,Minoru, Y. (deposition date: 2020-03-19, release date: 2021-03-24, Last modification date: 2023-11-29) |
Primary citation | Nielsen, A.L.,Rajabi, N.,Kudo, N.,Lundo, K.,Moreno-Yruela, C.,Baek, M.,Fontenas, M.,Lucidi, A.,Madsen, A.S.,Yoshida, M.,Olsen, C.A. Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration. Rsc Chem Biol, 2:612-626, 2021 Cited by PubMed: 34458803DOI: 10.1039/d0cb00036a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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