7BMK
ATP-Competitive Partial Antagonists-'PAIR's-Rheostatically Modulate IRE1alpha's Kinase Helix-alphaC to Segregate its RNase-Mediated Biological Outputs
Summary for 7BMK
Entry DOI | 10.2210/pdb7bmk/pdb |
Descriptor | Serine/threonine-protein kinase/endoribonuclease IRE1, 2,2,2-tris(fluoranyl)-~{N}-[4-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]ethanesulfonamide, GLYCEROL, ... (7 entities in total) |
Functional Keywords | kinase, kinase inhibitor, transferase, transferase inhibitor, unknown function |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 102917.21 |
Authors | Feldman, H.C.,Ghosh, R.,Auyeung, V.,Mueller, J.L.,Vidadala, V.N.,Olivier, A.,Backes, B.J.,Zikherman, J.,Papa, F.R.,Maly, D.J. (deposition date: 2021-01-20, release date: 2021-09-29, Last modification date: 2024-06-19) |
Primary citation | Feldman, H.C.,Ghosh, R.,Auyeung, V.C.,Mueller, J.L.,Kim, J.H.,Potter, Z.E.,Vidadala, V.N.,Perera, B.G.K.,Olivier, A.,Backes, B.J.,Zikherman, J.,Papa, F.R.,Maly, D.J. ATP-competitive partial antagonists of the IRE1 alpha RNase segregate outputs of the UPR. Nat.Chem.Biol., 17:1148-1156, 2021 Cited by PubMed: 34556859DOI: 10.1038/s41589-021-00852-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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