7BMK

ATP-Competitive Partial Antagonists-'PAIR's-Rheostatically Modulate IRE1alpha's Kinase Helix-alphaC to Segregate its RNase-Mediated Biological Outputs

7BMK の概要

• エントリーDOI: 10.2210/pdb7bmk/pdb
• 分子名称: Serine/threonine-protein kinase/endoribonuclease IRE1, 2,2,2-tris(fluoranyl)-~{N}-[4-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]ethanesulfonamide, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, transferase, transferase inhibitor, unknown function
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102917.21

構造登録者

Feldman, H.C.,Ghosh, R.,Auyeung, V.,Mueller, J.L.,Vidadala, V.N.,Olivier, A.,Backes, B.J.,Zikherman, J.,Papa, F.R.,Maly, D.J. (登録日: 2021-01-20, 公開日: 2021-09-29, 最終更新日: 2024-06-19)

• 主引用文献: Feldman, H.C.,Ghosh, R.,Auyeung, V.C.,Mueller, J.L.,Kim, J.H.,Potter, Z.E.,Vidadala, V.N.,Perera, B.G.K.,Olivier, A.,Backes, B.J.,Zikherman, J.,Papa, F.R.,Maly, D.J.; ATP-competitive partial antagonists of the IRE1 alpha RNase segregate outputs of the UPR.; Nat.Chem.Biol., 17:1148-1156, 2021; PubMed: 34556859; DOI: 10.1038/s41589-021-00852-0

実験手法

X-RAY DIFFRACTION (1.85 Å)