7BLE

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (3)

7BLE の概要

• エントリーDOI: 10.2210/pdb7ble/pdb
• 関連するPDBエントリー: 7BKG
• 分子名称: Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 3-ethyl-1,3-diazatricyclo[6.3.1.0^{4,12}]dodeca-4,6,8(12)-trien-2-imine, ... (4 entities in total)
• 機能のキーワード: methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128206.85

構造登録者

Schreuder, H.A.,Liesum, A. (登録日: 2021-01-18, 公開日: 2021-03-17, 最終更新日: 2024-01-31)

• 主引用文献: Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S.; Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.; Molecules, 26:-, 2021; PubMed: 33668468; DOI: 10.3390/molecules26040991

実験手法

X-RAY DIFFRACTION (2.809 Å)