7BJ6

Inhibitor of MDM2-p53 Interaction

7BJ6 の概要

• エントリーDOI: 10.2210/pdb7bj6/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: ligase, cell cycle, apoptosis, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12216.97

構造登録者

Williams, P.A. (登録日: 2021-01-14, 公開日: 2021-04-07, 最終更新日: 2021-04-21)

• 主引用文献: Chessari, G.,Hardcastle, I.R.,Ahn, J.S.,Anil, B.,Anscombe, E.,Bawn, R.H.,Bevan, L.D.,Blackburn, T.J.,Buck, I.,Cano, C.,Carbain, B.,Castro, J.,Cons, B.,Cully, S.J.,Endicott, J.A.,Fazal, L.,Golding, B.T.,Griffin, R.J.,Haggerty, K.,Harnor, S.J.,Hearn, K.,Hobson, S.,Holvey, R.S.,Howard, S.,Jennings, C.E.,Johnson, C.N.,Lunec, J.,Miller, D.C.,Newell, D.R.,Noble, M.E.M.,Reeks, J.,Revill, C.H.,Riedinger, C.,St Denis, J.D.,Tamanini, E.,Thomas, H.,Thompson, N.T.,Vinkovic, M.,Wedge, S.R.,Williams, P.A.,Wilsher, N.E.,Zhang, B.,Zhao, Y.; Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.; J.Med.Chem., 64:4071-4088, 2021; PubMed: 33761253; DOI: 10.1021/acs.jmedchem.0c02188

実験手法

X-RAY DIFFRACTION (1.59 Å)