7BII
Crystal structure of Nematocida HUWE1
Summary for 7BII
| Entry DOI | 10.2210/pdb7bii/pdb |
| Descriptor | E3 ubiquitin-protein ligase HUWE1 (1 entity in total) |
| Functional Keywords | hect e3 ligase, ubiquitin, protein quality control, ligase |
| Biological source | Nematocida sp. ERTm5 |
| Total number of polymer chains | 2 |
| Total formula weight | 575746.75 |
| Authors | Grabarczyk, D.B.,Petrova, O.A.,Meinhart, A.,Kessler, D.,Clausen, T. (deposition date: 2021-01-12, release date: 2021-07-28, Last modification date: 2024-01-31) |
| Primary citation | Grabarczyk, D.B.,Petrova, O.A.,Deszcz, L.,Kurzbauer, R.,Murphy, P.,Ahel, J.,Vogel, A.,Gogova, R.,Faas, V.,Kordic, D.,Schleiffer, A.,Meinhart, A.,Imre, R.,Lehner, A.,Neuhold, J.,Bader, G.,Stolt-Bergner, P.,Bottcher, J.,Wolkerstorfer, B.,Fischer, G.,Grishkovskaya, I.,Haselbach, D.,Kessler, D.,Clausen, T. HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain. Nat.Chem.Biol., 17:1084-1092, 2021 Cited by PubMed: 34294896DOI: 10.1038/s41589-021-00831-5 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.037 Å) |
Structure validation
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