7BGC
human butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor
Summary for 7BGC
Entry DOI | 10.2210/pdb7bgc/pdb |
Related | 1p0i |
Descriptor | Cholinesterase, SULFATE ION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | inhibitor, alzheimer, butyrylcholinesterase, tacrine, anacardic acid, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 64038.95 |
Authors | Nachon, F.,Salerno, A.,Bolognesi, M.L. (deposition date: 2021-01-06, release date: 2021-04-28, Last modification date: 2024-01-31) |
Primary citation | Rossi, M.,Freschi, M.,de Camargo Nascente, L.,Salerno, A.,de Melo Viana Teixeira, S.,Nachon, F.,Chantegreil, F.,Soukup, O.,Prchal, L.,Malaguti, M.,Bergamini, C.,Bartolini, M.,Angeloni, C.,Hrelia, S.,Soares Romeiro, L.A.,Bolognesi, M.L. Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. J.Med.Chem., 64:4972-4990, 2021 Cited by PubMed: 33829779DOI: 10.1021/acs.jmedchem.1c00048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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