7BD7
X-ray structure of Arsenoplatin-1-encapsulated horse spleen ferritin
Summary for 7BD7
| Entry DOI | 10.2210/pdb7bd7/pdb |
| Descriptor | Ferritin light chain, SODIUM ION, CADMIUM ION, ... (8 entities in total) |
| Functional Keywords | ferritin, drug delivery, metallodrug, arsenoplatin, anticancer, transport protein |
| Biological source | Equus caballus (Horse) |
| Total number of polymer chains | 1 |
| Total formula weight | 22108.15 |
| Authors | Ferraro, G.,Merlino, A. (deposition date: 2020-12-21, release date: 2021-03-17, Last modification date: 2024-01-31) |
| Primary citation | Ferraro, G.,Pratesi, A.,Cirri, D.,Imbimbo, P.,Maria Monti, D.,Messori, L.,Merlino, A. Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity. Int J Mol Sci, 22:-, 2021 Cited by PubMed Abstract: Arsenoplatin-1 (AP-1), the prototype of a novel class of metallodrugs containing a PtAs(OH) core, was encapsulated within the apoferritin (AFt) nanocage. UV-Vis absorption spectroscopy and inductively coupled plasma-atomic emission spectroscopy measurements confirmed metallodrug encapsulation and allowed us to determine the average amount of AP-1 trapped inside the cage. The X-ray structure of AP-1-encapsulated AFt was solved at 1.50 Å. Diffraction data revealed that an AP-1 fragment coordinates the side chain of a His residue. The biological activity of AP-1-loaded AFt was comparatively tested on a few representative cancer and non-cancer cell lines. Even though the presence of the cage reduces the overall cytotoxicity of AP-1, it improves its selectivity towards cancer cells. PubMed: 33668605DOI: 10.3390/ijms22041874 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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