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7BBL

Structure of human Gemin6/Gemin7/Gemin8 trimeric complex

Summary for 7BBL
Entry DOI10.2210/pdb7bbl/pdb
DescriptorGem-associated protein 6, Gem-associated protein 7, Gem-associated protein 8, ... (4 entities in total)
Functional Keywordsusnrnp, biogenesis, smn-complex, gemin8, splicing
Biological sourceHomo sapiens (Human)
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Total number of polymer chains6
Total formula weight50343.37
Authors
Viswanathan, A.,Grimm, C.,Fischer, U. (deposition date: 2020-12-17, release date: 2021-01-20, Last modification date: 2024-01-31)
Primary citationVeepaschit, J.,Viswanathan, A.,Bordonne, R.,Grimm, C.,Fischer, U.
Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.
Nucleic Acids Res., 49:7207-7223, 2021
Cited by
PubMed Abstract: The macromolecular SMN complex facilitates the formation of Sm-class ribonucleoproteins involved in mRNA processing (UsnRNPs). While biochemical studies have revealed key activities of the SMN complex, its structural investigation is lagging behind. Here we report on the identification and structural determination of the SMN complex from the lower eukaryote Schizosaccharomyces pombe, consisting of SMN, Gemin2, 6, 7, 8 and Sm proteins. The core of the SMN complex is formed by several copies of SMN tethered through its C-terminal alpha-helices arranged with alternating polarity. This creates a central platform onto which Gemin8 binds and recruits Gemins 6 and 7. The N-terminal parts of the SMN molecules extrude via flexible linkers from the core and enable binding of Gemin2 and Sm proteins. Our data identify the SMN complex as a multivalent hub where Sm proteins are collected in its periphery to allow their joining with UsnRNA.
PubMed: 33754639
DOI: 10.1093/nar/gkab158
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.521 Å)
Structure validation

243083

数据于2025-10-15公开中

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