7B8S
Fusidic acid bound structure of bacterial efflux pump.
Summary for 7B8S
Entry DOI | 10.2210/pdb7b8s/pdb |
Descriptor | Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, DARPin, FUSIDIC ACID, ... (4 entities in total) |
Functional Keywords | rnd transporter, multidrug resistance, efflux pump, antibiotics, transport protein |
Biological source | Escherichia coli (strain K12) More |
Total number of polymer chains | 6 |
Total formula weight | 253766.55 |
Authors | Wilhelm, J.,Sjuts, H.,Pos, K.M. (deposition date: 2020-12-13, release date: 2021-10-20, Last modification date: 2024-01-31) |
Primary citation | Ornik-Cha, A.,Wilhelm, J.,Kobylka, J.,Sjuts, H.,Vargiu, A.V.,Malloci, G.,Reitz, J.,Seybert, A.,Frangakis, A.S.,Pos, K.M. Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12:6919-6919, 2021 Cited by PubMed: 34824229DOI: 10.1038/s41467-021-27146-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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