7B4V

Broadly neutralizing DARPin bnD.2 in complex with the HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505)

7B4V の概要

• エントリーDOI: 10.2210/pdb7b4v/pdb
• 分子名称: Broadly neutralizing DARPin bnD.2, HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505), CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: hiv, v3, conformation, neutralization, darpins, antibodies, de novo protein
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 30971.14

構造登録者

Friedrich, N.,Stiegeler, E.,Glogl, M.,Lemmin, T.,Hansen, S.,Kadelka, C.,Wu, Y.,Ernst, P.,Maliqi, L.,Foulkes, C.,Morin, M.,Eroglu, M.,Liechti, T.,Ivan, B.,Reinberg, T.,Schaefer, J.,Karakus, U.,Ursprung, S.,Mann, A.,Rusert, P.,Kouyos, R.D.,Robinson, J.A.,Gunthard, H.F.,Pluckthun, A.,Trkola, A. (登録日: 2020-12-02, 公開日: 2021-11-24, 最終更新日: 2024-05-01)

• 主引用文献: Friedrich, N.,Stiegeler, E.,Glogl, M.,Lemmin, T.,Hansen, S.,Kadelka, C.,Wu, Y.,Ernst, P.,Maliqi, L.,Foulkes, C.,Morin, M.,Eroglu, M.,Liechti, T.,Ivan, B.,Reinberg, T.,Schaefer, J.V.,Karakus, U.,Ursprung, S.,Mann, A.,Rusert, P.,Kouyos, R.D.,Robinson, J.A.,Gunthard, H.F.,Pluckthun, A.,Trkola, A.; Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization.; Nat Commun, 12:6705-6705, 2021; PubMed: 34795280; DOI: 10.1038/s41467-021-27075-0

実験手法

X-RAY DIFFRACTION (1.4 Å)