7B3K
Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55)
Summary for 7B3K
Entry DOI | 10.2210/pdb7b3k/pdb |
Related | 1ze7 2llm |
NMR Information | BMRB: 34578 |
Descriptor | Isoform L-APP677 of Amyloid-beta precursor protein, D3 all D-enantimeric peptide (2 entities in total) |
Functional Keywords | d3-peptide, all-d-enantiomeric peptide, australian mutation, amyloid-beta, amyloid precursor protein, complex, transmembrane, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 7581.87 |
Authors | Bocharov, E.V.,Volynsky, P.E.,Okhrimenko, I.S.,Urban, A.S. (deposition date: 2020-12-01, release date: 2021-01-13, Last modification date: 2023-06-14) |
Primary citation | Bocharov, E.V.,Gremer, L.,Urban, A.S.,Okhrimenko, I.S.,Volynsky, P.E.,Nadezhdin, K.D.,Bocharova, O.V.,Kornilov, D.A.,Zagryadskaya, Y.A.,Kamynina, A.V.,Kuzmichev, P.K.,Kutzsche, J.,Bolakhrif, N.,Muller-Schiffmann, A.,Dencher, N.A.,Arseniev, A.S.,Efremov, R.G.,Gordeliy, V.I.,Willbold, D. All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64:16464-16479, 2021 Cited by PubMed: 34739758DOI: 10.1021/acs.jmedchem.1c00632 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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