7B3K

Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55)

7B3K の概要

• エントリーDOI: 10.2210/pdb7b3k/pdb
• 関連するPDBエントリー: 1ze7 2llm
• NMR情報: BMRB: 34578
• 分子名称: Isoform L-APP677 of Amyloid-beta precursor protein, D3 all D-enantimeric peptide (2 entities in total)
• 機能のキーワード: d3-peptide, all-d-enantiomeric peptide, australian mutation, amyloid-beta, amyloid precursor protein, complex, transmembrane, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7581.87

構造登録者

Bocharov, E.V.,Volynsky, P.E.,Okhrimenko, I.S.,Urban, A.S. (登録日: 2020-12-01, 公開日: 2021-01-13, 最終更新日: 2023-06-14)

• 主引用文献: Bocharov, E.V.,Gremer, L.,Urban, A.S.,Okhrimenko, I.S.,Volynsky, P.E.,Nadezhdin, K.D.,Bocharova, O.V.,Kornilov, D.A.,Zagryadskaya, Y.A.,Kamynina, A.V.,Kuzmichev, P.K.,Kutzsche, J.,Bolakhrif, N.,Muller-Schiffmann, A.,Dencher, N.A.,Arseniev, A.S.,Efremov, R.G.,Gordeliy, V.I.,Willbold, D.; All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors.; J.Med.Chem., 64:16464-16479, 2021; PubMed: 34739758; DOI: 10.1021/acs.jmedchem.1c00632

実験手法

SOLUTION NMR