7B3J
Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55)
Summary for 7B3J
Entry DOI | 10.2210/pdb7b3j/pdb |
Related | 1ze7 2llm |
NMR Information | BMRB: 34577 |
Descriptor | Isoform L-APP677 of Amyloid-beta precursor protein, D3 all D-enantimeric peptide (2 entities in total) |
Functional Keywords | d-peptide, amyloid-beta, complex, transmembrane, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 7597.91 |
Authors | Bocharov, E.V.,Volynsky, P.E.,Okhrimenko, I.S.,Urban, A.S. (deposition date: 2020-12-01, release date: 2021-01-13, Last modification date: 2021-12-08) |
Primary citation | Bocharov, E.V.,Gremer, L.,Urban, A.S.,Okhrimenko, I.S.,Volynsky, P.E.,Nadezhdin, K.D.,Bocharova, O.V.,Kornilov, D.A.,Zagryadskaya, Y.A.,Kamynina, A.V.,Kuzmichev, P.K.,Kutzsche, J.,Bolakhrif, N.,Muller-Schiffmann, A.,Dencher, N.A.,Arseniev, A.S.,Efremov, R.G.,Gordeliy, V.I.,Willbold, D. All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64:16464-16479, 2021 Cited by PubMed: 34739758DOI: 10.1021/acs.jmedchem.1c00632 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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