7B3B
Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1)
Summary for 7B3B
Entry DOI | 10.2210/pdb7b3b/pdb |
EMDB information | 11993 11994 11995 |
Descriptor | RNA-directed RNA polymerase nsp12, Non-structural protein 8, Non-structural protein 7, ... (6 entities in total) |
Functional Keywords | sars-cov-2, polymerase, transcription, replication, rna, remdesivir, inhibition, nucleotide analogue, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 5 |
Total formula weight | 161851.01 |
Authors | Kokic, G.,Hillen, H.S.,Tegunov, D.,Dienemann, C.,Seitz, F.,Schmitzova, J.,Farnung, L.,Siewert, A.,Hoebartner, C.,Cramer, P. (deposition date: 2020-11-30, release date: 2020-12-23, Last modification date: 2024-07-10) |
Primary citation | Kokic, G.,Hillen, H.S.,Tegunov, D.,Dienemann, C.,Seitz, F.,Schmitzova, J.,Farnung, L.,Siewert, A.,Hobartner, C.,Cramer, P. Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12:279-279, 2021 Cited by PubMed: 33436624DOI: 10.1038/s41467-020-20542-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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