7B36

MST4 in complex with compound G-5555

Summary for 7B36

• Entry DOI: 10.2210/pdb7b36/pdb
• Descriptor: Serine/threonine-protein kinase 26, 1,2-ETHANEDIOL, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one, ... (5 entities in total)
• Functional Keywords: kinase inhibitors, structure-based drug design, sik2 inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 68929.10

Authors

Tesch, R.,Rak, M.,Joerger, A.C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-28, release date: 2020-12-16, Last modification date: 2024-01-31)

• Primary citation: Tesch, R.,Rak, M.,Raab, M.,Berger, L.M.,Kronenberger, T.,Joerger, A.C.,Berger, B.T.,Abdi, I.,Hanke, T.,Poso, A.,Strebhardt, K.,Sanhaji, M.,Knapp, S.; Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.; J.Med.Chem., 64:8142-8160, 2021; PubMed: 34086472; DOI: 10.1021/acs.jmedchem.0c02144

Experimental method

X-RAY DIFFRACTION (2.10681078505 Å)