7B2Q
Cryo-EM structure of complement C4b in complex with nanobody B12
Summary for 7B2Q
Entry DOI | 10.2210/pdb7b2q/pdb |
Related | 7B2M 7B2P |
EMDB information | 11988 11989 11990 |
Descriptor | Complement C4 beta chain, Complement C4 alpha chain, Complement C4 gamma chain, ... (6 entities in total) |
Functional Keywords | complement, nanobody, c4b, inhibitor, complement classical pathway, nanobody-antigen complex, immune system |
Biological source | Lama glama (Llama) More |
Total number of polymer chains | 4 |
Total formula weight | 205508.37 |
Authors | Oosterheert, W.,De la O Becerra, K.I.,Gros, P. (deposition date: 2020-11-27, release date: 2022-03-02, Last modification date: 2022-05-04) |
Primary citation | De la O Becerra, K.I.,Oosterheert, W.,van den Bos, R.M.,Xenaki, K.T.,Lorent, J.H.,Ruyken, M.,Schouten, A.,Rooijakkers, S.H.M.,van Bergen En Henegouwen, P.M.P.,Gros, P. Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208:2207-2219, 2022 Cited by PubMed: 35428691DOI: 10.4049/jimmunol.2100647 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.76 Å) |
Structure validation
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