7B0T

Crystal structure of MLLT1 YEATS domain T3 mutant in complex with benzimidazole-amide based compound 1

7B0T の概要

• エントリーDOI: 10.2210/pdb7b0t/pdb
• 分子名称: Protein ENL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: t3 mutant, structural genomics, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18830.53

構造登録者

Ni, X.,Chaikuad, A.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-11-21, 公開日: 2021-02-17, 最終更新日: 2024-01-31)

• 主引用文献: Ni, X.,Londregan, A.T.,Owen, D.R.,Knapp, S.,Chaikuad, A.; Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.; Acs Chem.Biol., 16:571-578, 2021; PubMed: 33749253; DOI: 10.1021/acschembio.0c00960

実験手法

X-RAY DIFFRACTION (2.05 Å)