7B0S

TRPC4 in complex with inhibitor GFB-8438

7B0S の概要

• エントリーDOI: 10.2210/pdb7b0s/pdb
• EMDBエントリー: 11957 11968 11970
• 分子名称: Transient receptor potential cation channel subfamily c member 4a, 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{H}-pyridazin-6-one, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: ion channel, trpc4, inhibitor, membrane protein, transport protein
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 424295.90

構造登録者

Vinayagam, D.,Quentin, D.,Sistel, O.,Merino, F.,Stabrin, M.,Hofnagel, O.,Ledeboer, M.W.,Malojcic, G.,Raunser, S. (登録日: 2020-11-21, 公開日: 2020-12-09, 最終更新日: 2024-05-01)

• 主引用文献: Vinayagam, D.,Quentin, D.,Yu-Strzelczyk, J.,Sitsel, O.,Merino, F.,Stabrin, M.,Hofnagel, O.,Yu, M.,Ledeboer, M.W.,Nagel, G.,Malojcic, G.,Raunser, S.; Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.; Elife, 9:-, 2020; PubMed: 33236980; DOI: 10.7554/eLife.60603

実験手法

ELECTRON MICROSCOPY (3.6 Å)