7AZ0

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161

これはPDB形式変換不可エントリーです。

7AZ0 の概要

• エントリーDOI: 10.2210/pdb7az0/pdb
• 分子名称: N-glycosylase/DNA lyase, 2-cyclopropyl-~{N}-(4-iodophenyl)quinazolin-4-amine, NICKEL (II) ION, ... (4 entities in total)
• 機能のキーワード: 8-oxoguanine dna glycosylase, n-glycosylase, dna lyase, dna repair, dna binding protein
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 108283.09

構造登録者

Davies, J.R.,Masuyer, G.,Stenmark, P. (登録日: 2020-11-13, 公開日: 2022-06-01, 最終更新日: 2024-01-31)

• 主引用文献: Michel, M.,Benitez-Buelga, C.,Calvo, P.A.,Hanna, B.M.F.,Mortusewicz, O.,Masuyer, G.,Davies, J.,Wallner, O.,Sanjiv, K.,Albers, J.J.,Castaneda-Zegarra, S.,Jemth, A.S.,Visnes, T.,Sastre-Perona, A.,Danda, A.N.,Homan, E.J.,Marimuthu, K.,Zhenjun, Z.,Chi, C.N.,Sarno, A.,Wiita, E.,von Nicolai, C.,Komor, A.J.,Rajagopal, V.,Muller, S.,Hank, E.C.,Varga, M.,Scaletti, E.R.,Pandey, M.,Karsten, S.,Haslene-Hox, H.,Loevenich, S.,Marttila, P.,Rasti, A.,Mamonov, K.,Ortis, F.,Schomberg, F.,Loseva, O.,Stewart, J.,D'Arcy-Evans, N.,Koolmeister, T.,Henriksson, M.,Michel, D.,de Ory, A.,Acero, L.,Calvete, O.,Scobie, M.,Hertweck, C.,Vilotijevic, I.,Kalderen, C.,Osorio, A.,Perona, R.,Stolz, A.,Stenmark, P.,Berglund, U.W.,de Vega, M.,Helleday, T.; Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.; Science, 376:1471-1476, 2022; PubMed: 35737787; DOI: 10.1126/science.abf8980

実験手法

X-RAY DIFFRACTION (2.4 Å)