7AYN
Crystal structure of the lectin domain of the FimH variant Arg98Ala, in complex with Methyl 3-chloro-4-D-mannopyranosyloxy-3-biphenylcarboxylate
Summary for 7AYN
Entry DOI | 10.2210/pdb7ayn/pdb |
Descriptor | Type 1 fimbrin D-mannose specific adhesin, methyl 3-[3-chloranyl-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-phenyl]benzoate, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | adhesin, fimh, upec, bladder infection, carbohydrate, lectin, cell adhesion |
Biological source | Escherichia coli K12 |
Total number of polymer chains | 4 |
Total formula weight | 69270.43 |
Authors | Jakob, R.P.,Tomasic, T.,Rabbani, S.,Reisner, A.,Jakopin, Z.,Maier, T.,Ernst, B.,Anderluh, M. (deposition date: 2020-11-12, release date: 2020-12-23, Last modification date: 2024-01-31) |
Primary citation | Tomasic, T.,Rabbani, S.,Jakob, R.P.,Reisner, A.,Jakopin, Z.,Maier, T.,Ernst, B.,Anderluh, M. Does targeting Arg98 of FimH lead to high affinity antagonists? Eur.J.Med.Chem., 211:113093-113093, 2020 Cited by PubMed: 33340913DOI: 10.1016/j.ejmech.2020.113093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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