7AYE

Crystal structure of the computationally designed chemically disruptable heterodimer LD6-MDM2

7AYE の概要

• エントリーDOI: 10.2210/pdb7aye/pdb
• 分子名称: Isoform 11 of E3 ubiquitin-protein ligase Mdm2, Thiol:disulfide interchange protein DsbD (2 entities in total)
• 機能のキーワード: chemically disruptable heterodimer (cdh), protein-protein interaction, gene and cell therapy, protein switches, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28722.63

構造登録者

Yang, C.,Lau, K.,Pojer, F.,Correia, B.E. (登録日: 2020-11-12, 公開日: 2021-08-18, 最終更新日: 2024-01-31)

• 主引用文献: Shui, S.,Gainza, P.,Scheller, L.,Yang, C.,Kurumida, Y.,Rosset, S.,Georgeon, S.,Di Roberto, R.B.,Castellanos-Rueda, R.,Reddy, S.T.,Correia, B.E.; A rational blueprint for the design of chemically-controlled protein switches.; Nat Commun, 12:5754-5754, 2021; PubMed: 34599176; DOI: 10.1038/s41467-021-25735-9

実験手法

X-RAY DIFFRACTION (2.95 Å)