7AY6

Crystal structure of the PDE4D catalytic domain in complex with GEBR-41b

Summary for 7AY6

Entry DOI	10.2210/pdb7ay6/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 2-[(~{Z})-1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino]oxy-1-[(2~{S},6~{S})-2,6-dimethylmorpholin-4-yl]ethanone, ZINC ION, ... (6 entities in total)
Functional Keywords	phosphodiesterase 4d, inhibitor, complex, gebr, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	81253.10
Authors	Torretta, A.,Abbate, S.,Parisini, E. (deposition date: 2020-11-11, release date: 2021-06-30, Last modification date: 2024-01-31)
Primary citation	Brullo, C.,Rapetti, F.,Abbate, S.,Prosdocimi, T.,Torretta, A.,Semrau, M.,Massa, M.,Alfei, S.,Storici, P.,Parisini, E.,Bruno, O. Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors. Eur.J.Med.Chem., 223:113638-113638, 2021 Cited by PubMed: 34171658 DOI: 10.1016/j.ejmech.2021.113638 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation