7AXH
Crystal structure of the hPXR-LBD in complex with alpha-zearalanol
Summary for 7AXH
Entry DOI | 10.2210/pdb7axh/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2, ISOPROPYL ALCOHOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total) |
Functional Keywords | nuclear receptor hormone receptor pregnane x receptor, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36841.63 |
Authors | Huet, T.,Delfosse, V.,Bourguet, W. (deposition date: 2020-11-09, release date: 2021-01-13, Last modification date: 2024-01-31) |
Primary citation | Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33361153DOI: 10.1073/pnas.2020551118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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