7AWH
Crystal structure of human butyrylcholinesterase in complex with tert-butyl 3-(((2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)methyl)piperidine-1-carboxylate
Summary for 7AWH
Entry DOI | 10.2210/pdb7awh/pdb |
Descriptor | Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | butyrylcholinesterase, inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 63277.98 |
Authors | Brazzolotto, X.,Wichur, T.,Wieckowska, A. (deposition date: 2020-11-08, release date: 2021-09-29, Last modification date: 2024-01-31) |
Primary citation | Wichur, T.,Godyn, J.,Goral, I.,Latacz, G.,Bucki, A.,Siwek, A.,Gluch-Lutwin, M.,Mordyl, B.,Sniecikowska, J.,Walczak, M.,Knez, D.,Jukic, M.,Salat, K.,Gobec, S.,Kolaczkowski, M.,Malawska, B.,Brazzolotto, X.,Wieckowska, A. Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT 6 R antagonists with beta-amyloid anti-aggregation properties. Eur.J.Med.Chem., 225:113792-113792, 2021 Cited by PubMed: 34530376DOI: 10.1016/j.ejmech.2021.113792 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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