7AWE

HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid

7AWE の概要

• エントリーDOI: 10.2210/pdb7awe/pdb
• 分子名称: Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (18 entities in total)
• 機能のキーワード: multicatalytic proteinase, 20s proteasome, protease, hydrolase, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 695590.05

構造登録者

Musil, D.,Klein, M. (登録日: 2020-11-06, 公開日: 2021-06-09, 最終更新日: 2021-08-11)

• 主引用文献: Sanderson, M.P.,Friese-Hamim, M.,Walter-Bausch, G.,Busch, M.,Gaus, S.,Musil, D.,Rohdich, F.,Zanelli, U.,Downey-Kopyscinski, S.L.,Mitsiades, C.S.,Schadt, O.,Klein, M.,Esdar, C.; M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i) Delivering Efficacy in Multiple Myeloma Models.; Mol.Cancer Ther., 20:1378-1387, 2021; PubMed: 34045234; DOI: 10.1158/1535-7163.MCT-21-0005

実験手法

X-RAY DIFFRACTION (2.288 Å)