7AVQ
Crystal structure of haspin in complex with disubstituted imidazo[1,2- b]pyridazine inhibitor (compound 12)
7AVQ の概要
エントリーDOI | 10.2210/pdb7avq/pdb |
分子名称 | Serine/threonine-protein kinase haspin, (2~{R})-2-[[3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol, SODIUM ION, ... (6 entities in total) |
機能のキーワード | kinase, haspin, gsg2, inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 41359.20 |
構造登録者 | Chaikuad, A.,Bonnet, P.,Routier, S.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-11-05, 公開日: 2020-11-18, 最終更新日: 2024-01-31) |
主引用文献 | Elie, J.,Feizbakhsh, O.,Desban, N.,Josselin, B.,Baratte, B.,Bescond, A.,Duez, J.,Fant, X.,Bach, S.,Marie, D.,Place, M.,Ben Salah, S.,Chartier, A.,Berteina-Raboin, S.,Chaikuad, A.,Knapp, S.,Carles, F.,Bonnet, P.,Buron, F.,Routier, S.,Ruchaud, S. Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation. J Enzyme Inhib Med Chem, 35:1840-1853, 2020 Cited by PubMed: 33040634DOI: 10.1080/14756366.2020.1825408 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.65 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード