7AUV

The structure of ERK2 in complex with dual inhibitor ASTX029

7AUV の概要

• エントリーDOI: 10.2210/pdb7auv/pdb
• 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: mitogen activated kinase atp binding protein phosphorylation serine/threonine protein kinase, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43502.28

構造登録者

O'Reilly, M. (登録日: 2020-11-03, 公開日: 2021-10-06, 最終更新日: 2021-10-13)

• 主引用文献: Munck, J.M.,Berdini, V.,Bevan, L.,Brothwood, J.L.,Castro, J.,Courtin, A.,East, C.,Ferraldeschi, R.,Heightman, T.D.,Hindley, C.J.,Kucia-Tran, J.,Lyons, J.F.,Martins, V.,Muench, S.,Murray, C.W.,Norton, D.,O'Reilly, M.,Reader, M.,Rees, D.C.,Rich, S.J.,Richardson, C.J.,Shah, A.D.,Stanczuk, L.,Thompson, N.T.,Wilsher, N.E.,Woolford, A.J.,Wallis, N.G.; ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK.; Mol.Cancer Ther., 20:1757-1768, 2021; PubMed: 34330842; DOI: 10.1158/1535-7163.MCT-20-0909

実験手法

X-RAY DIFFRACTION (1.76 Å)