7AUE

Melanocortin receptor 4 (MC4R) Gs protein complex

Summary for 7AUE

• Entry DOI: 10.2210/pdb7aue/pdb
• EMDB information: 11927
• Descriptor: Melanocortin receptor 4, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (8 entities in total)
• Functional Keywords: mc4r, melanocortin, obesity, gpcr, agonist, setmelanotide, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 157802.70

Authors

Degtjarik, O.,Israeli, H.,Prabahar, V.,Shalev-Benami, M. (deposition date: 2020-11-02, release date: 2021-04-28, Last modification date: 2023-03-15)

• Primary citation: Israeli, H.,Degtjarik, O.,Fierro, F.,Chunilal, V.,Gill, A.K.,Roth, N.J.,Botta, J.,Prabahar, V.,Peleg, Y.,Chan, L.F.,Ben-Zvi, D.,McCormick, P.J.,Niv, M.Y.,Shalev-Benami, M.; Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.; Science, 372:808-814, 2021; PubMed: 33858992; DOI: 10.1126/science.abf7958

Experimental method

ELECTRON MICROSCOPY (2.97 Å)