7AT9

Structure of protein kinase ck2 catalytic subunit (csnk2a2 gene product) in complex with the ATP-competitive inhibitor MB002 and the alphaD-pocket ligand 3,4-dichlorophenethylamine

7AT9 の概要

• エントリーDOI: 10.2210/pdb7at9/pdb
• 分子名称: Casein kinase II subunit alpha', 2-(3,4-dichlorophenyl)ethanamine, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: protein kinase ck2, casein kinase 2, bivalent inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44304.16

構造登録者

Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Goetz, C.,Jose, J.,Niefind, K. (登録日: 2020-10-29, 公開日: 2021-08-04, 最終更新日: 2022-02-09)

• 主引用文献: Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Gotz, C.,Jose, J.,Niefind, K.; Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity.; J.Med.Chem., 65:1302-1312, 2022; PubMed: 34323071; DOI: 10.1021/acs.jmedchem.1c00063

実験手法

X-RAY DIFFRACTION (1.05 Å)