7ASJ

Crystal structure for the complex of human carbonic anhydrase II and 3-(3-methyl-3-phenethylureido)benzenesulfonamide

Summary for 7ASJ

Entry DOI	10.2210/pdb7asj/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	carbonic anhydrase ii, inhibitor, hca ii, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29802.96
Authors	Angeli, A.,Ferraroni, M. (deposition date: 2020-10-27, release date: 2021-11-24, Last modification date: 2024-01-31)
Primary citation	Vannozzi, G.,Vullo, D.,Angeli, A.,Ferraroni, M.,Combs, J.,Lomelino, C.,Andring, J.,Mckenna, R.,Bartolucci, G.,Pallecchi, M.,Lucarini, L.,Sgambellone, S.,Masini, E.,Carta, F.,Supuran, C.T. One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes. J.Med.Chem., 65:824-837, 2022 Cited by PubMed: 34958217 DOI: 10.1021/acs.jmedchem.1c01906 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation