7AS3

Influenza A PB2 (H357N mutation) in complex with VX-787

7AS3 の概要

• エントリーDOI: 10.2210/pdb7as3/pdb
• 分子名称: Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid (3 entities in total)
• 機能のキーワード: influenza a, polymerase, polymerase basic protein 2, vx787, viral protein
• 由来する生物種: Influenza A virus (A/California/07/2009(H1N1))
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20126.20

構造登録者

Radilova, K.,Brynda, J. (登録日: 2020-10-26, 公開日: 2021-02-24, 最終更新日: 2024-01-31)

• 主引用文献: Gregor, J.,Radilova, K.,Brynda, J.,Fanfrlik, J.,Konvalinka, J.,Kozisek, M.; Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase.; Molecules, 26:-, 2021; PubMed: 33673017; DOI: 10.3390/molecules26041007

実験手法

X-RAY DIFFRACTION (1.65 Å)