7AQ1

Crystal structure of human mature meprin beta in complex with the specific inhibitor MWT-S-270

Summary for 7AQ1

Entry DOI	10.2210/pdb7aq1/pdb
Descriptor	Meprin B subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	astacin protease, metalloproteinase, zn dependent, sheddase, gamma secretase, inhbibitor bound meprin beta holoenzyme, intermolecular disulfide bridge homodimer, glycoprotein, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	127877.33
Authors	Linnert, M.,Parthier, C.,Fritz, C. (deposition date: 2020-10-20, release date: 2021-03-03, Last modification date: 2024-01-31)
Primary citation	Linnert, M.,Fritz, C.,Jager, C.,Schlenzig, D.,Ramsbeck, D.,Kleinschmidt, M.,Wermann, M.,Demuth, H.U.,Parthier, C.,Schilling, S. Structure and Dynamics of Meprin beta in Complex with a Hydroxamate-Based Inhibitor. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 34073350 DOI: 10.3390/ijms22115651 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.413 Å)

Structure validation