7APJ
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
Summary for 7APJ
| Entry DOI | 10.2210/pdb7apj/pdb |
| Descriptor | RAC-alpha serine/threonine-protein kinase,Non-specific serine/threonine protein kinase,RAC-alpha serine/threonine-protein kinase, NB41 (3 entities in total) |
| Functional Keywords | kinase, autoinhibition, lipid, membrane, pip3, akt, signaling protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 65292.30 |
| Authors | Truebestein, L.,Hornegger, H.,Leonard, T.A. (deposition date: 2020-10-16, release date: 2021-08-25, Last modification date: 2024-01-31) |
| Primary citation | Truebestein, L.,Hornegger, H.,Anrather, D.,Hartl, M.,Fleming, K.D.,Stariha, J.T.B.,Pardon, E.,Steyaert, J.,Burke, J.E.,Leonard, T.A. Structure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34385319DOI: 10.1073/pnas.2101496118 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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